A token search of the Internet reveals a large selection of products which claim to facilitate the process of weight loss. Few are accompanied with appropriate scientific evidence.

The desperation of many overweight people can make them particularly receptive to "quick fixes" such as pills, potions and even creams which appear to offer the desired results without the effort of changing one's diet or lifestyle. As the critical focus on the weight loss industry sharpens, the more reputable companies are attempting to distance themselves from the rest by funding research into the efficacy of their products. Such a case study is described here.

Zotrim is a herbal food supplement, available in tablet form and based on pioneering work by Danish physician, Dr Lasse Hessel.

Zotrim contains active ingredients as extracts of the South American herbs Yerba mate' (leaves of Ilex paraguayensis), Guarana (seeds of Paullinia cupana) and Damiana (leaves of Turnera diffusa var. aphrodisiaca). An earlier clinical trial (Andersen and Fogh, 2001) found that 24 healthy overweight subjects who were given the Zotrim formulation three times per day before meals sustained a mean weight loss of 5.1kg after 45 days. The 23 subjects who were given the placebo showed a mean weight loss of only 0.3kg. Neither group received dietary advice. A follow-up of 22 subjects in the Zotrim group after an additional 12 months of treatment revealed that the initial weight loss was maintained. Mean weight at the start of the follow-up was 73kg, while after 12 months, it was 72.5kg.

It is strongly believed that Zotrim helps to reduce energy intake by delaying gastric emptying or by stimulating an early feeling of fullness.

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